Located in the heart of the old city, it is the most remarkable monument of the civil baroque niçois by its monumental staircase decorated with frescoes and its luxuriously decorated lounges.

The Palace was built in the middle of the 17th century, for the Lascaris-Vintimille that Charles Emmanuel II, Duc de Savoie, considered the "mainissima" of the families of the nobility niçoise, and in perpetuated fame. He remained the property of this family until the Revolution. He was put on sale in 1802 and suffered major deterioration. After graduating in 1942 by the city of Nice, he was the subject of a ranking for historical monuments in 1946.

Rehabilitation works began in 1963 and ended in 1970, when the palace was opened to the public as a municipal museum. It is, with the dozen religious buildings located in its near neighborhood, an exceptional set that declines all the successive phases of the evolution of the baroque architecture from the beginning of the 17th to the end of the 18th century.

The Palais Lascaris is labeled Museum of France.